SimplicityBio SA joins 3.2M Eurostars funded HeartLinc Program
17.07.2017
The venture leader and Venture Kick alumnus SimplicityBio SA joins 3.2M Eurostars funded HeartLinc Program led by the FIRALIS S.A. to develop lncRNA based IVD test for risk of developing heart failure (HF) after acute myocardial infarction (AMI).
 The team of SimplicityBio SA
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On 24 th of March 2017, the EU-funded (EUROSTAR) HeartLinc program has been launched in Seoul, South Korea, during a first meeting between the Seoul National University Hospital (SNUH), the QuantaMatrix company (Seoul, South Korea) and Firalis Group (Huningue, France). On 17th of June, the collaboration kicked off together with the European partners of the project: the Centre Hospitalier Universitaire (CHU) of Toulouse (France) and SimplicityBio (Monthey, Switzerland). In the frame of this €3.2 million research program, the consortium will develop an innovative in vitro diagnostic (IVD) test to assess the risk of developing heart failure (HF) after acute myocardial infarction (AMI). The test will be based on a unique profile of long noncoding RNAs (lncRNA).
The potential for lncRNAs in disease prediction, therapeutics, and companion diagnostics is widely recognized by the scientific community and the diagnostic industry. Despite the potential, no lncRNA-based products have been commercialised yet. Therefore, new lncRNAproducts would be considered as a breakthrough development, strongly stimulating the field of lncRNA-based research and development.
In this project, the consortium will develop an innovative in vitro diagnostic (IVD) test to assess the risk of developing HF after AMI. “The SNUH is very glad to contribute to this intercontinental project on a key pathology” said Hae-Young Lee, Associate Professor of Seoul National University Hospital.
The medical benefit of the IVD test will be validated in blood samples of European and Asian AMI patients. “We are now in a position to confirm the performance of our HEARTLINC IVD test simultaneously in Asia and in Europe” said Hueseyin Firat, CEO of Firalis.
The HeartLinc project will deliver an IVD test suitable for fast, multiplex, and high throughput HF prediction. This test will be an entirely new product and a breakthrough development. It will address an unmet medical need by identifying AMI patients at risk for HF, hence, allowing early treatment and monitoring treatment response. This is of particular importance in context of recently approved innovative drugs, such as Entresto.
The HEARTLINC testing will be available on an innovative multiplexed platform called Fi-MAP. This CE marked IVD platform has been developed by the innovative SME partner from Seoul, the QuantaMatrix. “Our proprietary technology will enable to show the use of FiMAP platform in the field of gene expression analysis and generation of IVD products” said Sunghoon Kwon, President & CEO of QuantaMatrix.
In order to reduce the incidence of HF, the HeartLinc test will help clinicians to apply a personalized treatment suitable for each individual patient. A predictive model will be established integrating the data from divers sources including clinical, biological and imaging data. SimplicityBio has developed new bioinformatics tools to discover and increase the performance of predictive models. “We are very happy to be part of the HeartLinc consortium developing the first precision medicine tool for the prediction and the management of AMIinduced heart Failure” said Dr. Matthew G. Hall, the founder & CEO of the company.
The availability of such a test would allow a more effective treatment and a drastic reduction of the burden of HF on healthcare systems.
Information about SimplicityBio:
SimplicityBio is an in-silico biomarker discovery company, identifying robust biomarkers for diagnostics and prognostics with its proprietary algorithms and technology. SimplicityBio collaborates with biotechnology and pharmaceutical companies to create robust models combining biomarkers panels based on omics and clinical data, with humanly interpretable rules. These unique models bring new molecular diagnostic tests to the market and enable patient stratification to develop more effective drugs.
The potential for lncRNAs in disease prediction, therapeutics, and companion diagnostics is widely recognized by the scientific community and the diagnostic industry. Despite the potential, no lncRNA-based products have been commercialised yet. Therefore, new lncRNAproducts would be considered as a breakthrough development, strongly stimulating the field of lncRNA-based research and development.
In this project, the consortium will develop an innovative in vitro diagnostic (IVD) test to assess the risk of developing HF after AMI. “The SNUH is very glad to contribute to this intercontinental project on a key pathology” said Hae-Young Lee, Associate Professor of Seoul National University Hospital.
The medical benefit of the IVD test will be validated in blood samples of European and Asian AMI patients. “We are now in a position to confirm the performance of our HEARTLINC IVD test simultaneously in Asia and in Europe” said Hueseyin Firat, CEO of Firalis.
The HeartLinc project will deliver an IVD test suitable for fast, multiplex, and high throughput HF prediction. This test will be an entirely new product and a breakthrough development. It will address an unmet medical need by identifying AMI patients at risk for HF, hence, allowing early treatment and monitoring treatment response. This is of particular importance in context of recently approved innovative drugs, such as Entresto.
The HEARTLINC testing will be available on an innovative multiplexed platform called Fi-MAP. This CE marked IVD platform has been developed by the innovative SME partner from Seoul, the QuantaMatrix. “Our proprietary technology will enable to show the use of FiMAP platform in the field of gene expression analysis and generation of IVD products” said Sunghoon Kwon, President & CEO of QuantaMatrix.
In order to reduce the incidence of HF, the HeartLinc test will help clinicians to apply a personalized treatment suitable for each individual patient. A predictive model will be established integrating the data from divers sources including clinical, biological and imaging data. SimplicityBio has developed new bioinformatics tools to discover and increase the performance of predictive models. “We are very happy to be part of the HeartLinc consortium developing the first precision medicine tool for the prediction and the management of AMIinduced heart Failure” said Dr. Matthew G. Hall, the founder & CEO of the company.
The availability of such a test would allow a more effective treatment and a drastic reduction of the burden of HF on healthcare systems.
Information about SimplicityBio:
SimplicityBio is an in-silico biomarker discovery company, identifying robust biomarkers for diagnostics and prognostics with its proprietary algorithms and technology. SimplicityBio collaborates with biotechnology and pharmaceutical companies to create robust models combining biomarkers panels based on omics and clinical data, with humanly interpretable rules. These unique models bring new molecular diagnostic tests to the market and enable patient stratification to develop more effective drugs.